Comparative study of the haemagglutination test and a simple latex-fixation test for the detection of the rheumatoid factor.
نویسنده
چکیده
The exact nature of the "rheumatoid factor" is unknown, but it appears to be an antibody-like substance composed of a gamma globulin complex of high molecular weight. Two groups of tests have been used to detect it: the haemagglutination test and the latex-fixation or Bentonite flocculation test. In the first group the indicator consists of sheep red cells with rabbit anti-sheep haemolysin as the reactant. In the second group the indicators are either polystyrene latex particles or bentonite particles with gamma globulin as the reactant. In both groups of tests the indicator becomes sensitized or coated with reactant which then reacts with sera containing the rheumatoid factor, causing agglutination of the indicator. In the following series of 176 cases, serum from each case was examined for the rheumatoid factor, using a standard haemagglutination test and a simple slide latex-fixation test.
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ورودعنوان ژورنال:
- Annals of the rheumatic diseases
دوره 18 شماره
صفحات -
تاریخ انتشار 1959